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 On the threshold of this new science we find inscribed the principle of the conservation of energy, which has been presented to us by some as Nature's supreme law, and which we may say dominates natural philosophy. Its discovery marked a new era and accomplished a profound revolution in our conception of the universe. It is due to a doctor, Robert Mayer, who practised in a little town in Wurtemberg, and who formulated the new principle in 1842, and afterwards developed its consequences in a series of publications between 1845 and 1851. They remained almost unknown until Helmholtz, in his celebrated memoir on the conservation of force, brought them to light and gave them the importance they deserved. From that time forward the name of the doctor of Heilbronn, until then obscure, has taken its place among the most honoured names in the history of science. *