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10 as have liv'd long in France, and the City of Paris; where, to take off that unjust reproch, the Plague as seldome domineers, as in any part of Europe, which I more impute to the Serenity and Purity of the Aer about it, then to any other qualities which are frequently assign'd for the cause of it by divers Writers. But if it be objected that the purest Aers are soonest infected; it is answered, that they are also the soonest freed again; and that none would therefore choose to live in a corrupt Aer, because of this Article: London 'tis confess'd, is not the only City most obnoxious to the Pestilence; but it is yet never clear of this Smoake which is a Plague so many other ways, and indeed intolerable; because it kills not at once, but always, since still to languish, is worse then even Death it self. For is there under Heaven such Coughing and Snuffing to be heard, as in the London Churches and AssemliesAssemblies [sic] of People, where the Barking and the Spitting is uncessant and most importunate. What shall I say?

And what may be the cause of these troublesome effects, but the inspiration of this infernal vapour, accompaning the Aer, which first heats and sollicits the Aspera Arteria, through one of whose Conduits, partly Cartilaginous, and partly membranous, it enters by several branches into the very Parenchyma, and substance of the Lungs, violating, in this passage, the Larynx and Epiglottis, together with those multiform and curious Muscles, the immediate and proper Instruments of the Voyce, which becoming rough and drye, can neither be contracted, or dilated for the due modulation of the Voyce; so as by some of my Friends (studious in Musick, and whereof one is a Doctor of Physick) it has been constantly observ'd, that coming out of the Country into London, they lost Three whole Notes in the compasse of their Voice, which they never recover'd again till their retreat; Adeo enim Animantes (to use the Orators words) aspiratione Aeris sustinentur, ipseque Aer nobiscum videt, nobiscum audit, nobiscum sonat: In summe, we perform nothing without it.

Whether the Head and the Brain (as some have imagined) take in the ambient Aer, nay the very Arteries through the skin universally over the whole body, is greatly controverted; But if so, of what consequence the goodnesse and purity of the Aer is, will to every one appear: Sure we are, how much the Respiration is Rh