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 I have known Hypochondriack and Hysterical women complain of great Degrees of Coldness, that would suddenly invade some particular part, chiefly of the Head or Back, and be for a good while troublesome there. And that, if a frigorific vapour or matter be exceeding subtile, an inconsiderable Quantity of it being dispersed through the bloud may suffice to produce a notable Refrigeration, I have learnt by Inquiry into the Effects of some Poysons; and 'tis not very material, whether the Poyson, generally speaking, be cold or hot, if it meet with a body dispos'd to have those affections that pass for cold ones produced in it. For I have made a Chymical Liquor, that was penetrant and fiery enough to the Taste, and had acquired a Subtlety and briskness from Distillation, with which I could almost in a trice, giving it but in the quantity of about a drop, cast an Animal into that which appear'd a sleep, and the like