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 in Agues there is some morbifick matter of a viscous or not easily dissipable texture, that is harbor'd in some part of the body, and requires such a time to be made fluid and resolvable; the Cold Fits of Agues need not be so much admired as they usually are; since, though just before the Fit the same parcel of matter that is to produce it were actually in the body, yet it was not by reason of its clamminess actually resolved into small parts, and mingled with those of the bloud, and consequently could not make such a change in the motion of that liquor as is felt in the Cold Fit of an Ague; (for, of the further Change that occasions the Hot Fit, I am not here to speak) And in some other Diseases a small quantity of matter, being resolved into minute parts, may be able to produce a great sense of Coldness in some part of a body, which by reason of the structure of that part may be peculiarly disposed to be affected thereby; as