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 and flax. The highest inhabited place is Frankenhausen, lying at a height of 2350 ft. with 6383 inhabitants (1900). The nearer (Vordere) Rhön, forming the northern side of the range, is more attractive, with forests and deep and fertile valleys.

See Lenk, Zur geologischen Kenntnis der südlichen Rhön (Würzburg, 1887); Scheidtweiler, Die Rhön und ihre wirthschaftlichen Verhältnisse (Frankfort, 1887); and Daniel, Deutschland (5th ed., Leipzig, 1878).

RHOXOLANI, a Sarmatian tribe defeated in the Crimea by Diophantus, general of Mithradates, c. 100, and by the Romans on the lower Danube c. 60, and also under M. Aurelius. They seem to have finally succumbed to the Goths.

 RHUBARB. This name is applied both to a drug and to a vegetable.

1. The drug has been used in medicine from very early times, being described in the Chinese herbal Pen-king, which is believed to date from 2700 B.C. The name seems to be a corruption of Rheum barbarum or Reu barbarum, a designation applied to the drug as early as the middle of the 6th century, and apparently identical with the ρῆον or ρᾶ of Dioscorides, described by him as a root brought from beyond the Bosporus. In the 14th century rhubarb appears to have found its way to Europe by way of the Indus and Persian Gulf to the Red Sea and Alexandria, and was therefore described as “ East Indian ” rhubarb. Some also came by way of Persia and the Caspian to Syria and Asia Minor, and reached Europe from the ports of Aleppo and Smyrna, and became known as “ Turkey ” rhubarb. Subsequently to the year 1653, when China first permitted Russia to trade on her frontiers, Chinese rhubarb reached Europe chiefly by way of Moscow; and in 1704 the rhubarb trade became a monopoly of the Russian government, in consequence of which the term “ Russian ” or “ crown ” rhubarb came to be applied to it. Urga was the great depot for the rhubarb trade in 1719, but in 1728 the depot was transferred to Kiachta. All rhubarb brought to the depot passed through the hands of the government inspector; hence Russian rhubarb was invariably good and obtained a remarkably high price. This severe supervision naturally led, as soon as the northern Chinese ports were thrown open to European trade, to a new outlet being sought; and the increased demand for the drug at these ports resulted in less care being exercised by the Chinese in the collection and curing of the root, so that the rhubarb of good quality offered at Kiachta rapidly dwindled in quantity, and after 1860 Russian rhubarb ceased to appear in European commerce. Owing to the expense of carrying the drug across the whole breadth of Asia, and the difficulty of preserving it from the attacks of insects, rhubarb was formerly one of the most costly of drugs. In 1542 it was sold in France for ten times the price of cinnamon and four times that of saffron, and in an English price list bearing date of 1657 it is quoted at 16s. per ℔, opium being at that time only 6s. and scammony 12s. per ℔.

The dose of rhubarb is anything from ½ up to 30 grains, according to the action which is desired. The British Pharmacopeia contains seven preparations, only one of which is of any special value. This is the Pulvis Rhei Compositus, or Gregory's powder, which is composed of 2 parts of rhubarb, 6 of heavy or light magnesia and 1 of ginger. The dose is 20 to 60 gr.

Rhubarb is used in small doses—½ to 2 gr.—as an astringent tonic, since it stimulates all the functions of the upper part of the alimentary canal. In many cases of torpid dyspepsia it is very efficient when combined with the sub nitrate of bismuth and the bicarbonate of sodium. The more characteristic action of rhubarb, however, is purgation, which it causes in doses of 15 gr. and upwards. The action occurs within seven or eight hours, a soft, pulpy motion of a yellow colour being produced. The colour is due to the chrysarobin, which is also the purgative constituent of the drug. Rhubarb is also a secretory cholagogue, increasing the amount of bile formed by the liver. The drug is apt to cause colic, and should therefore never be given alone. The ginger in Gregory's powder averts this unpleasant consequence of the aperient properties of rhubarb. The drug is peculiar in that the purgation is succeeded by definite constipation, said to be due to the rheotannic acid. This explanation is hardly satisfactory, however, since it is difficult to see how the rheotannic acid can be retained in the bowel during the process of purgation. Rhubarb has, therefore, definite indications and contra-indications. It is obviously worse than, useless in the treatment of chronic constipation, which it only aggravates. On the other hand, it is very valuable in children and others, when diarrhoea has been caused by an unsuitable dietary. The drug removes the indigestible residue of the food and then gives the bowel rest. Rhubarb is also useful in the weaning of infants, since it, is partly excreted in the maternal milk, and gives it a bitter taste which the baby dislikes.

Some chrysarobin is absorbed and is excreted in the urine, which it slightly increases and colours a reddish brown. The colour is discharged by the addition of a little dilute hydrochloric acid to the urine.

The botanical source of Chinese rhubarb cannot be said to have been as yet definitely cleared up by actual identification of plants observed to be used for the purpose. Rheum palmatum, R. officinale, R. palmatum, var. tangulicum, R. colinianum and R. Franzenbachii have been variously stated to be the source of it, but the roots produced by these species under cultivation in Europe do not present the characteristic network of white veins exhibited by the best specimens of the Chinese drug.

Chemistry.—The most important constituent of this drug, giving it its purgative properties and its yellow colour, is chrysarobin, C30H26O7, formerly known as rhein or chrysophan. The rhubarb of commerce also contains chrysophanic acid, a dioxymethyl anthraquinone, C14H5(CH3)O2(OH)2, of which chrysarobin is a reduction product. Nearly 40% of the drug consists of calcium oxalate, which gives it the characteristic grittiness. There is also present rheotannic acid, which is ofisome practical importance. There are numerous other constituents, such as emodin, C15H10O5, mucilage, resins, rheumic acid, C20H15O9, aporrhetin, &c. Production and Commerce.—Rhubarb is produced in the four northern provinces of China proper (Chih-li, Shan-se, Shen-se and Ho-nan), in the north-west provinces of Kan-suh, formerly included in Shen-se, but now extending across the desert of Gobi to the frontier of Tibet, in the Mongolian province of 'Tsing-hai, including the salt lake Koko-nor, and the districts of Tangut, Sifan and Turfan, and in the mountains of the western provinces of Sze-chuen. Two of the most important centres of the trade are Sining-fuin the province of Kan-suh, and Kwanhien in Sze-chuen. From Shen-se, Kan-suh and Sze-chuen the rhubarb is forwarded to Hankow, and thence carried to Shanghai, whence it is shipped to Europe. Lesser quantities are shipped from Tien-tsin, and occasionally the drug is exported from Canton, Amoy, Fuh-chow and Ning-po.

Very little is known concerning the mode of preparing the drug for the market. According to Mr Bell, who on a journey from St Petersburg to Peking had the opportunity of observing the plant in a growing state, the root is not considered to be mature until it is six years old. It is then dug up, usually in the autumn, and deprived of its cortical portion and smaller branches, and the larger pieces are divided in half longitudinally; these pieces are bored with holes and strung up on cords to dry, in some cases being previously sulgected to a preliminary drying on stone slabs heated by fire un erneath. In Bhutan the root is said to be hung up in a kind of drying room, in which a moderate heat is regularly maintained. The effect produced by the two drying processes is very different: when dried by artificial heat, the exterior of the pieces becomes hardened before the interior has entirely lost its moisture, and consequently the pieces decay in the centre, although the surface may show no change. These two varieties are technically known as kiln-dried and sun-dried; and it was on account of this difference in quality that the Russian officer at Kiachta had every piece examined by boring a hole to its centre.

European Rhubarb.—As early as 1608 Prosper Alpinus of Padua cultivated as the true rhubarb a plant which is now known as Rheum rhaponticum, a native of southern Siberia and the basin of the Volga. This plant was introduced into England through Sir Matthew Lister, physician to Charles I., who gave seed obtained by him in Italy to the botanist Parkinson. The culture of, this rhubarb for the sake of the root was commenced in 1777 at Banbury, in Oxfordshire, by an apothecary named Hayward, the plants being raised from seed sent from Russia in 1762, and with such success that the Society of Arts awarded him a silver medal in 1789 and a gold one in 1794. The cultivation subsequently extended to Somersetshire, Yorkshire, and Middlesex, but is now chiefly carried on at Banbury. English rhubarb root is sold at a cheaper rate than the Chinese rhubarb, and forms a considerable article of export to America, and is said to be used in Britain in the form of powder, which is of a finer yellow colour than that of Chinese rhubarb. The Banbury rhubarb appears to be a hybrid between R. rhaponticum and R. undulatum—the root, according to E. Colin, not presenting the typical microscopic structure of the former. More recently very