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Rh 1787 (where he proposed the famous “New Jersey Plan”), a United States Senator in 1780–1790, governor of the state in 1790–1793, and an associate justice of the United States Supreme Court from 1793 until his death. Paterson was incorporated as a township in 1831, chartered as a city in 1851 and rechartered in 1861. Three great industries—the manufacture of cotton, machinery and silk—were established in Paterson almost contemporaneously with their introduction into the United States. In 1793 the first cotton yarn was spun at Paterson in a mill run by ox-power, and in the next year, when the dams and reservoir were completed, Paterson’s first cotton factory began its operations. After 1840 the manufacture of machinery and of silk gradually supplanted that of cotton goods. Although an attempt was made to manufacture machinery in Paterson as early as 1800, there was little progress until after 1825. The building of the “Sandusky,” Paterson’s first locomotive, in 1837, marked the beginning of a new industry, and before 1860 the city was supplying locomotives to all parts of the United States and to Mexico and South America. By 1840 the silk industry had obtained a footing, and after this date there was a steady advance in the quantity and quality of the product. From 1872 to 1881 inclusive Paterson consumed two-thirds of the raw silk imported into the country.

 PATEY, JANET MONACH (1842–1894), English vocalist, was born in London on the 1st of May 1842, her maiden name being Whytock. She had a fine alto voice, which developed into a contralto, and she studied singing under J. Wass, Pinsuti and Mrs Sims Reeves. Miss Whytock’s first appearance, as a child, was made at Birmingham, and her first regular engagement was in 1865, in the provinces. From 1866, in which year she sang at the Worcester festival, and married John Patey, a bass singer, she was recognized as one of the leading contraltos; and on the retirement of Mme Sainton-Dolby in 1870 Mme Patey was without a rival whether in oratorio or in ballad music. She toured in America in 1871, sang in Paris in 1875, and in Australia in 1890. She died at Sheffield on the 28th of February 1894.  PATHAN, the name applied throughout India to the Afghans, especially to those permanently settled in the country and to those dwelling on the borderland. It is apparently derived from the Afghan name for their own language, Pushtu or Pukhtu, and may be traced back to the Paktues of Herodotus. In 1901 the total number of Pathans in all India was nearly 3 millions, but the speakers of Pushtu numbered less than 1 millions. The name is frequently, but incorrectly, applied to the Mahommedan dynasties that preceded the Moguls at Delhi, and also to the style of architecture employed by them; but of these dynasties only the Lodis were Afghans.

The Pathans of the Indian borderland inhabit the mountainous country on the Punjab frontier, stretching northwards from a line drawn roughly across the southern border of the Dera Ismail Khan district. South of this line are the Baluchis. The Pathans include all the strongest and most warlike tribes of the North-West frontier of India, such as the Afridis, Orakzais, Waziris, Mohmands, Swatis and many other clans. Those in the settled districts of the North-West Frontier Province (in 1901) numbered 883,779, or more than two-fifths of the population. Each of the principal divisions is dealt with separately in this work under its tribal name. The Pathans are split up into different tribes, each tribe into clans, and each clan into sections, so that the nomenclature is often very puzzling. The tribe, clan and section are alike distinguished by patronymics formed from the name of the common ancestor by the addition of the word zai or khel; zai being a corruption of the Pushtu word zoe, meaning son, while khel is an Arabic word meaning an association or company. Both terms are used indifferently for both the larger and smaller divisions. Pathans enlist largely in the native army of India; and since the frontier risings of 1897 they have been formed with increasing frequency into class-regiments and regiments of native militia. They make excellent soldiers. The greater part

of the Pathan country was placed under British political control by the Durand agreement made with the Amir of Afghanistan in 1893.  PATHOLOGY (from Gr. , suffering), the science dealing with the theory or causation of disease. The term by itself is usually applied to animal or human pathology, rather than to vegetable pathology or Phytopathology (see : Pathology).

The outstanding feature in the history of pathology during the 19th century, and more particularly of the latter half of it, was the completion of its rescue from the thraldom of abstract philosophy, and its elevation to the dignity of one of the natural sciences. Our forefathers, if one may venture to criticize them, were too impatient. Influenced by the prevailing philosophy of the day, they interpreted the phenomena of disease through its lights, and endeavoured from time to time to reduce the study of pathology to philosophical order when the very elements of philosophical order were wanting. The pathology of the present day is more modest; it is content to labour and to wait. Whatever its faults may be—and it is for our successors to judge of these—there is this to be said in its favour: that it is in nowise dogmatic. The eloquence of facts appeals to the scientific mind nowadays much more than the assertion of crude and unproven principles. The complexity and mystery of action inherent in living matter have probably been accountable for much of the vague philosophy of disease in the past, and have furnished one reason at least why pathology has been so long in asserting its independence as a science. This, indeed, holds good of the study of biology in general. There are other factors, however, which have kept pathology in the background. Its existence as a science could never have been recognized so long as the subjects of physics, chemistry and biology, in the widest acceptation of the term, remained unevolved. Pathology, in fact, is the child of this ancestry; it begins where they end.

Progress in the study of pathology has been greatly facilitated by the introduction of improved methods of technique. The

certainty with which tissues can now be fixed in the state they were in when living, and the delicacy with which they can be stained differentially, have been the means of opening up a new world of exploration. Experimental pathology has benefited by the use of antiseptic surgery in operations upon animals, and by the adoption of exact methods of recording; while the employment of solid culture media in bacteriology—the product of Koch’s fertile genius—is responsible for a great part of the extraordinary development which has taken place in this department of pathological research. The discoveries made in pathological bacteriology, indeed, must be held to be among the most brilliant of the age. Inaugurated by Pasteur’s early work, progress in this subject was first marked by the discovery of the parasite of anthrax and of those organisms productive of fowl-cholera and septic disease. Then followed Koch’s great revelation in 1882 of the bacillus of tubercle (fig. 22, Pl. II.), succeeded by the isolation of the organisms of typhoid, cholera, diphtheria, actinomycosis, tetanus, &c. The knowledge we now possess of the causes of immunity from contagious disease has resulted from this study of pathological bacteriology: momentous practical issues have also followed upon this study. Amongst these may be mentioned the neutralizing of the toxins in cases of diphtheria, tetanus and poisonous snake-bite; “serum therapeutics”; and treatment by “vaccines.” By means of “vaccination” we are enabled to induce an active immunity against infection by certain pathogenic bacteria. The value of such protective inoculations is demonstrated in the treatment against small-pox (Jenner), cholera, plague (Haffkine) and typhoid (Wright and Semple). Pasteur’s inoculation against hydrophobia is on the same principle. “Vaccines” are also used as a method of treatment during the progress of the disease. Sir A. Wright and others, in recent work on opsonins, have shown that, by injecting dead cultures of the causal agent into subjects infected with the organism, there is produced in the body fluids a substance (opsonin) which apparently in favourable conditions unites with the living causal bacteria and so sensitizes them that they are