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 a hospital with 1500 beds are the more remarkable of the modern buildings of the town. Angers is the seat of a bishopric, dating from the 3rd century, a prefecture, a court of appeal and a court of assizes. It has a tribunal of first instance, a tribunal of commerce, a board of trade-arbitrators, a chamber of commerce, a branch of the Bank of France and several learned societies. Its educational institutions include ecclesiastical seminaries, a lycée, a preparatory school of medicine and pharmacy, a university with free faculties (facultés libres) of theology, law, letters and science, a higher school of agriculture, training colleges, a school of arts and handicrafts and a school of fine art. The prosperity of the town is largely due to the great slate-quarries of the vicinity, but the distillation of liqueurs from fruit, cable, rope and thread-making, and the manufacture of boots and shoes, umbrellas and parasols are leading industries. The weaving of sail-cloth and woollen and other fabrics, machine construction, wire-drawing, and manufacture of sparkling wines and preserved fruits are also carried on. The chief articles of commerce, besides slate and manufactured goods, are hemp, early vegetables, fruit, flowers and live-stock.

Angers, capital of the Gallic tribe of the Andecavi, was under the Romans called Juliomagus. During the 9th century it became the seat of the counts of (q.v.). It suffered severely from the invasions of the Northmen in 845 and the succeeding years, and of the English in the 12th and 15th centuries; the Huguenots took it in 1585, and the Vendean royalists were repulsed near it in 1793. Till the Revolution, Angers was the seat of a celebrated university founded in the 14th century.

ANGERSTEIN, JOHN JULIUS (1735–1822), London merchant, and patron of the fine arts, was born at St Petersburg and settled in London about 1749. His collection of paintings, consisting of about forty of the most exquisite specimens of the art, purchased by the British government, on his death, formed the nucleus of the National Gallery. ANGILBERT (d. 814), Frankish Latin poet, and minister of Charlemagne, was of noble Frankish parentage, and educated at the palace school under Alcuin. As the friend and adviser of the emperor’s son, Pippin, he assisted for a while in the government of Italy, and was later sent on three important embassies to the pope, in 792, 794 and 796. Although he was the father of two children by Charlemagne’s daughter, Bertha, one of them named Nithard, we have no authentic account of his marriage, and from 790 he was abbot of St Riquier, where his brilliant rule gained for him later the renown of a saint. Angilbert, however, was little like the true medieval saint; his poems reveal rather the culture and tastes of a man of the world, enjoying the closest intimacy with the imperial family. He accompanied Charlemagne to Rome in 800 and was one of the witnesses to his will in 814. Angilbert was the Homer of the emperor’s literary circle, and was the probable author of an epic, of which the fragment which has been preserved describes the life at the palace and the meeting between Charlemagne and Leo III. It is a mosaic from Virgil, Ovid, Lucan and Fortunatus, composed in the manner of Einhard’s use of Suetonius, and exhibits a true poetic gift. Of the shorter poems, besides the greeting to Pippin on his return from the campaign against the Avars (796), an epistle to David (Charlemagne) incidentally reveals a delightful picture of the poet living with his children in a house surrounded by pleasant gardens near the emperor’s palace. The reference to Bertha, however, is distant and respectful, her name occurring merely on the list of princesses to whom he sends his salutation.

ANGINA PECTORIS (Latin for “pain of the chest”), a term applied to a violent paroxysm of pain, arising almost invariably in connexion with disease of the coronary arteries, a lesion causing progressive degeneration of the heart muscle (see : Disease). An attack of angina pectoris usually comes on with a sudden seizure of pain, felt at first over the region of the heart, but radiating through the chest in various directions, and frequently extending down the left arm. A feeling of constriction and of suffocation accompanies the pain, although there is seldom actual difficulty in breathing. When the attack comes on, as it often does, in the course of some bodily exertion, the sufferer is at once brought to rest, and during the continuance of the paroxysm experiences the most intense agony. The countenance becomes pale, the surface of the body cold, the pulse feeble, and death appears to be imminent, when suddenly the attack subsides and complete relief is obtained. The duration of a paroxysm rarely exceeds two or three minutes, but it may last for a longer period. The attacks are apt to recur on slight exertion, and even in aggravated cases without any such exciting cause. Occasionally the first seizure proves fatal; but more commonly death takes place as the result of repeated attacks. Angina pectoris is extremely rare under middle life, and is much more common in males than in females. It must always be regarded as a disorder of a very serious nature. In the treatment of the paroxysm, nitrite of amyl has now replaced all other remedies. It can be carried by the patient in the form of nitrite of amyl pearls, each pearl containing the dose prescribed by the physician. Kept in this way the drug does not lose strength. As soon as the pain begins the patient crushes a pearl in his handkerchief and holds it to his mouth and nose. The relief given in this way is marvellous and usually takes place within a very few seconds. In the rare cases where this drug does not relieve, hypodermic injections of morphia are used. But on account of the well-known dangers of this drug, it should only be administered by a medical man. To prevent recurrence of the attacks something may be done by scrupulous attention to the general health, and by the avoidance of mental and physical strain. But the most important preventive of all is “bed,” of which fourteen days must be enforced on the least premonition of anginal pain.

Pseudo-angina.—In connexion with angina pectoris, a far more common condition must be mentioned that has now universally received the name of pseudo-angina. This includes the praecordial pains which very closely resemble those of true angina. The essential difference lies in the fact that pseudo-angina is independent of structural disease of the heart and coronary arteries. In true angina there is some condition within the heart which starts the stimulus sent to the nerve centres. In pseudo-angina the starting-point is not the heart but some peripheral or visceral nerve. The impulse passes thence to the medulla, and so reaching the sensory centres starts a feeling of pain that radiates into the chest or down the arm. There are three main varieties:—(1) the reflex, (2) the vaso-motor, (3) the toxic. The reflex is by far the most common, and is generally due to irritation from one of the abdominal organs. An attack of pseudo-angina may be agonizing, the pain radiating through the chest and into the left arm, but the patient does not usually assume the motionless attitude of true angina, and the duration of the seizure is usually much longer. The treatment is that of the underlying neurosis and the prognosis is a good one, sudden death not occurring. ANGIOSPERMS. The botanical term “Angiosperm” (, receptacle, and  , seed) was coined in the form Angiospermae by Paul Hermann in 1690, as the name of that one of his primary divisions of the plant kingdom, which included flowering plants possessing seeds enclosed in capsules, in contradistinction to his Gymnospermae, or flowering plants with achenial or schizo-carpic fruits—the whole fruit or each of its pieces being here regarded as a seed and naked. The term and its antonym were maintained by Linnaeus with the same sense, but with restricted application, in the names of the orders of his class Didynamia. Its use with any approach to its modern scope only became possible after Robert Brown had established in 1827 the existence of truly naked seeds in the Cycadeae and Coniferae, entitling them to be correctly called Gymnosperms. From that time onwards, so long as these Gymnosperms were, as was usual, reckoned as dicotyledonous flowering plants, the term Angiosperm was used antithetically by botanical writers, but with varying limitation, as a group-name for other