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 summon up courage to have the tooth drawn. Morton, greatly excited, told his patient that he could do better for him than mesmerising him. He could take the tooth out without pain if he would consent. The sufferer agreed eagerly, and Morton, with two assistants, proceeded to operate. A handkerchief, saturated with ether, was applied to the mouth and nostrils, and unconsciousness was produced almost immediately. A tooth, a firmly-rooted bicuspid, was extracted without arousing the patient. Then followed a minute of intense fear. The man remained motionless, and Morton felt convinced he was dead. Seizing a glass of water he dashed it into the face of this first subject, who at once revived. "Are you ready to have your tooth drawn?" asked Morton. Rather hesitating assent was given, and then the extracted tooth was shown to the patient in the chair. His name, which ought to be recorded in the annals of surgery, was Eben Frost.

On October 16, 1846, a tumour was removed from a patient at the Massachusetts General Hospital, Boston. Morton administered the ether, and Dr. Collins Warren, the senior surgeon, operated. The patient made no sound, and after he recovered consciousness declared that he had experienced no pain. "Gentlemen, this is no humbug," said Dr. Warren to the other surgeons who had witnessed the operation. Morton died in 1868.

The first operation under ether in Great Britain was performed by Liston at University College Hospital in December, 1846. In January, 1847, James Young Simpson commenced to employ it in midwifery cases in Edinburgh. Simpson had already acquired a high reputation as a gynecologist, and was an enthusiast in his profession. Delighted though he was with the results of his trials of ether, he felt sure that an anæsthetic with