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 Burrhus, who had wearied him with his remonstrances. Locusta was executed in the reign of Galba 68.

Among other famous Romans believed to have perished by poison were Germanicus and Drusus. Caligula ordered a deadly ointment to be given to an impolitic gladiator named Columbus, who had unwisely worsted the emperor with the fencing foils, to be applied to his wounds. The poor wretch died in consequence. These are only samples of Roman poisonings.

The poisons known to the ancients cannot be with certainty identified. The one to which the power of philtres was principally attributed was mandragora, which was said to produce various hallucinations and temporary madness. It is most likely, however, that in many of the cases where this drug is named the poison actually used was belladonna root. Hannibal, fighting against a large army of African rebels, simulated retreat, but left on the field of battle a quantity of vases of wine in which "mandragora" had been infused. The savages drank the wine, which reduced them to a condition of stupor. Then the Carthaginian hero returned and gained an easy victory over his helpless foes. Henbane seeds infused in wine made the head light, and gave the impression of having travelled through the air. Stramonium, dulcamara, hellebore, opium, Indian hemp, vervain, mezereon, and many other drugs, were in the stock-in-trade of the philtre mongers and conjurers, and the legends related by Pliny and others about the properties possessed by these herbs are sometimes nonsense, but are too often based on their real powers.