Page:Chronicles of pharmacy (Volume 2).djvu/221

 evidence was given before a Royal Commission, appointed to inquire into the health of the Indian Army, by Major-General Cottin R.E., who stated that many great engineering works carried on in "deadly jungles" had been brought to a successful issue mainly through the protection afforded to the workmen by this tincture. In an article published in the Lancet, November 15, 1875, Professor W. C. Maclean, Inspector General of the Army, gave still more striking testimony. He said he had treated remittent fevers of every degree of severity contracted in India, China, and the Gold Coast, and had never known quinine when given alone act in the characteristic manner of this tincture. A dose of 9-1/2 grains of quinine in Warburg's Tincture would often not only arrest the exacerbation of the fever but would frequently prevent its recurrence. He had never known quinine have that effect. In the same article Professor Maclean published the formula for the tincture which Dr. Warburg had confided to him on the advice of his friends. It was as follows:—Socotrine aloes 1 lb.; East India rhubarb, angelica seeds, confectio Damocratis, of each, 4 oz.; elecampane, fennel seed, saffron, prepared chalk, of each 2 oz.; gentian root, zedoary root, cubebs, picked myrrh, camphor, larch agaric, of each 1 oz. Digest these ingredients in 500 ounces of proof spirit in a water bath for 12 hours, express, and add 10 oz. of sulphate of quinine. Replace the mixture in the water bath till the quinine is dissolved, and filter.

The tincture was supplied in 1 oz. bottles, and 1/2 oz. was given for a dose after the bowels had been evacuated. The other 1/2 oz. was given 3 hours after.

Three years later Professor Maclean wrote to the Times stating that Dr. Carl Warburg was living in