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 America, but they differ considerably. Paris in "Pharmacologia" said they were a compound of aloes and jalap with oil of anise; the French Codex which adopted them, or at least the name, compounded them of aloes and gamboge with oil of anise; Niemann, whose formulary had a quasi-official sanction in Holland early in the nineteenth century gave a much more complicated recipe, adding to the aloes both jalap and gamboge, together with sulphur, burnt ivory, liquorice powder, and soap. "Pharmaceutical Formulas" states that they are well represented by Pil Aloes et Myrrhæ B.P., "which (saving excipient) contains the same ingredients as those mentioned in a copy of the original document deposited in the Rolls House."

Anodyne necklaces were perhaps the most extensively advertised of the quack remedies of the eighteenth century. The introduction of them is generally attributed to one of the Chamberlen family, well known in medical history as the inventors of the modern midwifery forceps.

In a collection of quack advertisements in the British Museum, all published in the last half of the seventeenth century, there is a handbill issued by Major John Coke, "a licensed physician and one of his Majesty's Chymists" advertising miraculous necklaces for children breeding teeth "preventing (by God's assistance) feavers, convulsions, ruptures, chincough, ricketts, and such attendant distempers." These are 5s. each. A number of titled people whose children have used these necklaces are named. A correspondent of Notes and Queries (Mr. J. Elliot Hodgkin, 6th Ser.,