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These pills acquired extraordinary popularity, particularly in Scotland and France, and to some extent in other countries, including England. Either these pills or Singleton's Eye Ointment is the proprietary remedy still sold in this country with the longest history. It is claimed that the ointment was invented some forty years earlier than the pills, but it must be admitted that the records of the latter, especially in their early days, are more exactly authenticated.

, M.D.

Dr. Patrick Anderson was a Scotch physician of considerable reputation in London in the Stuart period. He is described on some of his books as Physician to Charles I. In 1635 he published a treatise entitled as follows:—"Grana Angelica; hoc est pilularum hujus nominis insignis utilitas; quibus etiam accesserunt alia quaedam pancula de durioris alvi incommodis propter materiam cognitionem, ac vice supplementi in fine