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 P.L., 1746, Pil. Saponacea, was adapted from a famous nostrum long sold as Matthews's Pills, and as Starkey's Pills. Starkey, a qualified physician, was understood to have devised the process, and Matthews was the vendor in whose name they were sold. But a little before his death in 1665 Starkey told Dr. George Wilson that the formula he had sold to Matthews was not his genuine and best process. In both, however, the characteristic ingredient was "soap of tartar," which it was claimed added an aperient quality to the opium which made it safe to give in asthmas and other complaints when opium alone was objectionable. The soap of tartar was made by melting together in a crucible equal parts of cream of tartar and saltpetre, the compound being afterwards crystallised and powdered, and with it was incorporated 4 oz. of turpentine to each pound of the resulting salt. Matthews's Pills were made from 4 oz. each of extract of opium, black hellebore, soap of tartar, and liquorice, with 1 oz. of saffron. Starkey's deathbed formula ordered 4 oz. of extract of opium, 2 oz. each of nutmeg and mineral bezoar (calx of antimony), saffron and snake root, of each 1 oz., soap of tartar 8 oz., oil of sassafras 1/2 oz., tincture of antimony, 2 oz. These pills were also known as pilulæ pacificæ.

Sarsaparilla, guaiacum, sassafras, and mezereon enjoyed fitful periods of fame in the sixteenth, seventeenth and eighteenth centuries, especially for the treatment of syphilis. From the time of their introduction the Paracelsists denounced these remedies, and Paracelsus himself was especially sarcastic about "the wooden doctors," as he called those who relied on these woods. Still they were