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 But a more serious danger now appeared in Ireland. Gerald, Earl of Kildare, the Lord Deputy, who had used the King's artillery for his own castles, had been summoned to England in 1533, but delays ensued, and he only arrived in London in the spring of 1534, suffering from a wound that he had received in an encounter, and not likely to live long. He was not at first imprisoned, and efforts were made to lure his son, Lord Thomas Fitzgerald, over to England. But the young man (deceived, it is said, by a false report of his father's execution) rebelled, declaring that he upheld the Pope's cause and that the King's adherents were accursed. He murdered Archbishop Alien of Dublin, the Chancellor of Ireland (July 28), as he was endeavouring to sail for England, and became for a short time virtual ruler of the country, which he ordered all the English to quit on pain of death. Piers Butler, Earl of Ossory, however, made a stand for the King at Waterford, and Lord Thomas was compelled to raise the siege laid by him to Dublin, when Sir William Skeffington, appointed a second time as Lord Deputy, arrived from Wales in October; after which matters began to mend.

In England, to complete the work of the year, Parliament met in November, and passed, among other legislation, Acts for confirming the King's title as Supreme Head of the Church, for granting him the first-fruits and tenths before paid to the Pope, and for attainting More and Fisher of misprision and the Earl of Kildare of treason. But Parliament passed measures at dictation, and several of the chief lords of England were in secret communication with the imperial ambassador Chapuys to urge the Emperor to invade England.

Cromwell was now appointed the King's Vicar-General in spiritual things, and in the spring of 1535 the Act of Supremacy began to be put into execution. An oath to the succession of Anne Boleyn's issue had already been extorted in the previous year from the monks of the Charter House, which some of them seem not to have taken until after a significant visit from one of the London Sheriffs. But now they were required to swear to the supremacy in derogation of the Pope's authority. Prior Houghton, with two other Priors of the Order who had lately come up to London, approached Cromwell at the Rolls in the hope of obtaining some mitigation of the terms required; but unconditional acknowledgment of the King's supremacy was insisted on. All three refused, and repeated their refusal a few days later in the Tower. They were tried in April, together with Dr Reynolds of the Brigettine Monastery of Sion, who, having been also committed to the Tower, had joined in their refusal; and all received sentence together. With them also were condemned, for a private conversation about the King's tyranny and licentiousness, John Hale, vicar of Isleworth, and a young priest named Robert Feron; but the latter had his pardon after sentence, having turned King's evidence. All the others were hanged at Tyburn on May 4, with even more than the usual barbarities.