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24 remained so. On 12th November treated with quinine by a doctor called in to see him. Became semi-conscious again. No vomiting. Delirious at night. Chest normal. Admitted, 15th November. Semi-comatose all day. Wife said he had never been ill. Liver and spleen enlarged. Urine passed in bed. Skin yellow and slightly cyanosed. Pupils contracted. Blood examined and showed enormous numbers of sub-tertian parasites in all stages of growth; as many as four present in some corpuscles, and in very many two. Quinine given hypodermically and per rectum. Condition, however, became worse, and patient died at 12.30 on 17th. (Here was a man, without an obtainable history, showing no evident signs of malaria and undiagnosable without blood examination. Had a blood examination been made by the doctor who saw him on the 12th, and maximal doses of quinine been forthwith given, he might possibly have recovered.)

Case 13. W. L., 49, from Tampico, Gulf of Mexico. On voyage home became feverish; this lasted four days, then he completely went off his head, and only came round on arrival in dock on 14th October 1901, when he was admitted. Liver enlarged. Splenic area