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 for Holabird, who gave up and retired to his den (or so Martin gloomily believed) to devise new ways of plaguing him. For a time Martin was again left free to wallow in work.

He found a means of reproducing phage on dead bacteria by a very complicated, very delicate use of partial oxygen-carbon dioxide tension—as exquisite as cameo-carving, as improbable as weighing the stars. His report stirred the laboratory world, and here and there (in Tokio, in Amsterdam, in Winnemac) enthusiasts believed he had proven that phage was a living organism; and other enthusiasts said, in esoteric language with mathematical formulæ, that he was a liar and six kinds of a fool.

It was at this time, when he might have become a Great Man, that he pitched over most of his own work and some of the duties of being Joyce's husband to follow Terry Wickett, which showed that he lacked common sense, because Terry was still an assistant while he himself was head of a department.

Terry had discovered that certain quinine derivatives when introduced into the animal body slowly decompose into products which are highly toxic to bacteria but only mildly toxic to the body. There was hinted here a whole new world of therapy. Terry explained it to Martin, and invited him to collaborate. Buoyant with great things they got leave from Holabird—and from Joyce—and though it was winter they went off to Birdies' Rest, in the Vermont hills. While they snowshoed and shot rabbits, and all the long dark evenings while they lay on their bellies before the fire, they ranted and planned.

Martin had not been so long silk-wrapped that he could not enjoy gobbling salt pork after the northwest wind and the snow. It was not unpleasant to be free of thinking up new compliments for Joyce.

They had, they saw, to answer an interesting question: Do the quinine derivatives act by attaching themselves to the bacteria, or by changing the body fluids? It was a simple, clear, definite question which required for answer only the inmost knowledge of chemistry and biology, a few hundred animals on which to experiment, and perhaps ten or twenty or a million years of trying and failing.

They decided to work with the pneumococcus, and with the animal which should most nearly reproduce human pneumonia.